Energy & Fatigue
Energy that holds.
Energy & Fatigue
What's happening
Persistent low energy rarely has a single cause. More often it reflects a combination of depleted cellular ATP regeneration, micronutrient shortfalls, and mitochondrial cofactor inadequacy. Creatine raises intramuscular phosphocreatine. The fast-cycling ATP buffer used by skeletal muscle, brain, and any tissue with brief high-power demand. The B-vitamins are cofactors across the citric acid cycle, fatty-acid β-oxidation, and the mitochondrial electron transport chain. Every B-vitamin in Rōnin carries the GB-NHC authorised claim "contributes to normal energy-yielding metabolism". Ubiquinol (CoQ10) is the mitochondrial electron carrier between complexes I and III; plasma CoQ10 declines with age. This combination addresses energy at the cellular level, not the symptom.
Evidence. Peer-reviewed, PubMed-verified
Creatine. Kreider ISSN position stand (Kreider 2017, J Int Soc Sports Nutr); Branch meta-analysis of 96 studies (Branch 2003, Int J Sport Nutr Exerc Metab); Rae brain-bioenergetics RCT (Rae 2003, Proc Biol Sci). [GB-NHC] Creatine increases physical performance in successive bursts of short-term, high-intensity exercise (≥3 g/day; Rōnin delivers 5 g).
CoQ10 (Ubiquinol). Langsjoen plasma-uptake comparison (Langsjoen 2014, Clin Pharmacol Drug Dev); Mantle bioavailability review (Mantle 2020, Antioxidants); Ernster biochemistry canonical (Ernster 1995, Biochim Biophys Acta).
NAD⁺ & Niacinamide (B3). Mehmel nicotinamide riboside review (Mehmel 2020, Nutrients); Massudi tissue NAD⁺ with age (Massudi 2012, PLoS One); Kolotyeva contemporary NAD⁺ biology (Kolotyeva 2024, Biomolecules).
Full register: /pages/research.
How Rōnin addresses it
| Ingredient | Dose | Role |
|---|---|---|
| Creatine Monohydrate | 5,000mg | Phosphocreatine pool; ATP resynthesis in muscle and brain |
| Taurine | 2,000mg | ~70 mmol/L in skeletal muscle; mitochondrial membrane stability |
| Vitamin B3 (Niacinamide) | 500mg | NAD⁺ precursor; [GB-NHC] normal energy-yielding metabolism |
| Vitamin B5 (Pantothenic acid) | 6mg | Coenzyme A synthesis; fatty acid + carb oxidation |
| Vitamin B2 (Riboflavin) | 2.8mg | FAD/FMN cofactors at complex I and II of ETC |
| Vitamin B1 (Thiamine) | 2.2mg | Pyruvate dehydrogenase / α-KG dehydrogenase cofactor |
| Vitamin B6 (P-5-P) | 2.8mg | ~140 PLP-dependent enzymes; one-carbon metabolism |
| Ubiquinol (CoQ10) | 100mg | Mitochondrial electron carrier (complex I → III) |
| Magnesium Bisglycinate | 200mg elemental | Mg-ATP complex formation; required cofactor for >600 enzymes |
| Iodine | 150µg | T3/T4 thyroid hormone substrate; basal metabolic rate |
All ingredients listed are included in the Rōnin Daily Formula at the stated doses. One daily scoop.