PERFORMANCE & RECOVERY - RŌNIN V4.1
Why 2,000mg of Glycine?
Inhibitory neurotransmitter that lowers core body temperature at night, improving sleep onset and quality. Also the rate-limiting amino acid for both collagen and glutathione synthesis.
- CATEGORY
- Performance
- DOSE
- 2,000mg
- FORM
- Free amino acid - pharmaceutical grade
- EVIDENCE LEVEL
- Strong - multiple RCTs
How Glycine works
Glycine is the simplest amino acid and acts as an inhibitory neurotransmitter in the central nervous system. It activates glycine receptors that suppress neuronal excitability - lowering core body temperature by 0.5-1°C, a key trigger for sleep onset.
Beyond sleep, glycine is the rate-limiting substrate for glutathione synthesis (the body's primary antioxidant) and for collagen production. Tissue glycine concentrations decline with age, making supplementation increasingly relevant.
Key benefits
- Conditionally essential amino acid, demand increases with age
- Simplest of the 20 proteinogenic amino acids, pharmacopoeial grade ≥99%
- Rate-limiting substrate for glutathione synthesis
- Essential for collagen and connective tissue production
- Conditionally essential amino acid. Demand increases with age
The research
Peer-reviewed human trials supporting this ingredient at this dose.
- New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.PubMed →
- GlyNAC supplementation in older adults improves glutathione deficiency, oxidative stress, and mitochondrial dysfunction.PubMed →
- An update of the promise of glycine supplementation for enhancing physical performance and recovery.PubMed →
IN THE FORMULA
Glycine
2,000mg
Free-form amino acid
WHEN TO TAKE IT
Best taken at night, 30-60 minutes before sleep. Glycine lowers core body temperature - the physiological signal that initiates sleep onset.