Glycine
Inhibitory neurotransmitter that lowers core body temperature at night, improving sleep onset and quality. Also the rate-limiting amino acid for both collagen and glutathione synthesis.
Mechanism
Glycine is the simplest amino acid and acts as an inhibitory neurotransmitter in the central nervous system. It activates glycine receptors that suppress neuronal excitability - lowering core body temperature by 0.5-1°C, a key trigger for sleep onset.
Beyond sleep, glycine is the rate-limiting substrate for glutathione synthesis (the body's primary antioxidant) and for collagen production. Tissue glycine concentrations decline with age, making supplementation increasingly relevant.
Key Benefits
- Conditionally essential amino acid, demand increases with age
- Simplest of the 20 proteinogenic amino acids, pharmacopoeial grade ≥99%
- Rate-limiting substrate for glutathione synthesis
- Essential for collagen and connective tissue production
- Conditionally essential amino acid. Demand increases with age
The Research
Peer-reviewed human trials supporting this ingredient at this dose.
Glycine
2,000mgFree amino acid - pharmaceutical grade
Best taken at night, 30-60 minutes before sleep. Glycine lowers core body temperature - the physiological signal that initiates sleep onset.