Why 2.8mg of Vitamin B6?

How Vitamin B6 works

Pyridoxal-5-phosphate (P-5-P) is the biologically active cofactor form of vitamin B6, serving as a coenzyme for over 100 aminotransferases and decarboxylases. Its functions include: transamination (the metabolic shuffling of amino groups between amino acids); decarboxylation of 5-HTP → serotonin, DOPA → dopamine, and glutamate → GABA; and methylation of homocysteine via cystathionine beta-synthase (in conjunction with B12 and folate).

Most B6 supplements use pyridoxine hydrochloride - the cheapest form, which requires two hepatic enzyme steps to convert to P-5-P. This conversion is rate-limited and can be impaired in individuals with hepatic dysfunction. P-5-P bypasses this entirely.

Key benefits

• Active form - no hepatic conversion required
• Required for serotonin, dopamine, and GABA synthesis
• Key participant in homocysteine clearance with B12 and folate
• Cofactor for 100+ aminotransferases and decarboxylases
• Supports red blood cell haemoglobin synthesis

The researchGB-NHC

Peer-reviewed human trials supporting this ingredient at this dose.

1. Rall LC, Meydani SN. (1993). Nutr Rev. 51(8):217-25.Vitamin B6 and immune competence.PubMed →
2. Stover PJ, Field MS. (2015). Adv Nutr. 6(1):132-3.Vitamin B-6.PubMed →
3. Ito T. (2022). Biosci Biotechnol Biochem. 86(11):1457-66.Role of the conserved pyridoxal 5'-phosphate-binding protein YggS/PLPBP in vitamin B6 and amino acid homeostasis.PubMed →

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