Why 100mcg of Selenium?

How Selenium works

Selenium is incorporated as selenocysteine - the 21st amino acid - into 25 distinct selenoproteins. The most functionally critical are: glutathione peroxidases (GPx1-6), which reduce hydrogen peroxide and lipid hydroperoxides using glutathione as electron donor; thioredoxin reductases (TrxR1-3), which regenerate reduced thioredoxin to support cellular redox balance; and iodothyronine deiodinases, which convert T4 to the active T3 thyroid hormone.

L-selenomethionine - the organic form - has approximately 90% bioavailability compared to ~50% for inorganic sodium selenite. The organic form incorporates into tissue proteins (including skeletal muscle) as a body selenium reservoir, providing more stable tissue levels between doses.

Key benefits

• Component of glutathione peroxidases - reduces lipid peroxides
• Required for T4 → T3 thyroid hormone activation
• L-selenomethionine: ~90% bioavailability vs ~50% for selenite
• Builds tissue selenium reservoir in skeletal muscle
• 55mcg = 100% NRV - within safe distance from upper limit

The researchGB-NHC

Peer-reviewed human trials supporting this ingredient at this dose.

1. Rayman MP. (2012). Lancet. 379(9822):1256-68.Selenium and human health.PubMed →
2. Fairweather-Tait SJ, et al. (2011). Antioxid Redox Signal. 14(7):1337-83.Selenium in human health and disease.PubMed →
3. Jäger T, et al. (2016). Arch Toxicol. 90(1):149-58.Human metabolism and renal excretion of selenium compounds after oral ingestion of sodium selenite and selenized yeast.PubMed →

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