Ubiquinol (CoQ10)

100mg

The active, reduced form of CoQ10 - 8x more bioavailable than ubiquinone. Required by every mitochondria to produce ATP via the electron transport chain. Naturally declines from age 30.

Category Mitochondrial
Dose 100mg
Form Active reduced form - Kaneka QH grade
Evidence Level Strong - multiple clinical studies

Mechanism

Coenzyme Q10 (CoQ10) is an endogenous lipid-soluble antioxidant and a critical component of the mitochondrial electron transport chain (complexes I, II, and III). In its reduced ubiquinol form, it accepts electrons and transfers them along the chain, driving the proton gradient required for ATP synthesis.

Ubiquinol is the dominant form in plasma and tissues. Ubiquinone (the oxidised form used in most cheaper products) must be converted to ubiquinol before it's functional - a conversion step that becomes less efficient with age. Kaneka QH is the gold-standard pharmaceutical grade, produced via fermentation.

Key Benefits

  • Essential for mitochondrial ATP production
  • 8? superior absorption vs ubiquinone (oxidised form)
  • Ubiquinol is the reduced, active form of CoQ10 — Kaneka QH-grade
  • Powerful lipid-soluble antioxidant protecting cell membranes
  • Component of the mitochondrial electron-transport chain

The Research

Peer-reviewed human trials supporting this ingredient at this dose.

Langsjoen PH, Langsjoen AM. (2014). Clin Pharmacol Drug Dev. 3(1):13-7.Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone.PubMed →
Zozina VI, et al. (2018). Curr Cardiol Rev. 14(3):164-74.Coenzyme Q10 in cardiovascular and metabolic diseases: current state of the problem.PubMed →
Mantle D, Dybring A. (2020). Antioxidants (Basel). 9(5):386.Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism.PubMed →
Ernster L, Dallner G. (1995). Biochim Biophys Acta. 1271(1):195-204.Biochemical, physiological and medical aspects of ubiquinone function.PubMed →
In the formula

Ubiquinol (CoQ10)

100mg

Active reduced form - Kaneka QH grade

When to take it

Take with food containing fat - CoQ10 is fat-soluble and absorption increases significantly when taken with dietary fat.