Why 200mg of Alpha Lipoic Acid?

How Alpha Lipoic Acid works

Alpha lipoic acid (ALA) is a potent antioxidant synthesised endogenously in mitochondria. Its unique dual solubility - both fat-soluble and water-soluble - means it can neutralise free radicals in both lipid membranes and aqueous cellular environments, unlike vitamin C (water-soluble only) or vitamin E (fat-soluble only).

ALA regenerates oxidised forms of glutathione, vitamin C, and vitamin E, amplifying the entire antioxidant network. It also acts as a mitochondrial cofactor for key energy-producing enzymes, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase.

Key benefits

• Both fat- and water-soluble - active in all tissue compartments
• Regenerates vitamins C and E and glutathione
• Mitochondrial cofactor for energy metabolism enzymes
• Part of the cellular antioxidant network studied extensively in mitochondrial research
• R-form has higher bioavailability than racemic ALA

The research

Peer-reviewed human trials supporting this ingredient at this dose.

1. Packer L, et al. (1995). Free Radic Biol Med. 19(2):227-50.Alpha-lipoic acid as a biological antioxidant.PubMed →
2. Shay KP, et al. (2009). Biochim Biophys Acta. 1790(10):1149-60.Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.PubMed →
3. Isenmann E, et al. (2020). J Int Soc Sports Nutr. 17(1):61.The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation.PubMed →
4. Ziegler D, et al. (2004). Diabet Med. 21(2):114-21.Alpha-lipoic acid effects on peripheral nerve function: a meta-analysis of clinical studies.PubMed →

Works well with