Why 750mg of Xylitol?

How Xylitol works

Xylitol is a five-carbon sugar alcohol that Streptococcus mutans - the primary oral caries-causing bacterium - actively transports into its cytoplasm via the phosphoenolpyruvate phosphotransferase system. Inside the cell, xylitol-5-phosphate cannot be metabolised further and accumulates, disrupting energy metabolism and inhibiting bacterial growth and acid production. Importantly, repeated exposure to xylitol selects for S. mutans strains with reduced virulence, providing long-term plaque-reducing benefit.

As a sweetener, xylitol has a glycaemic index of ~7 vs 65 for glucose, producing minimal insulin response. At 2g per serving, it improves the palatability of a 50-ingredient formula without contributing to blood glucose or dental acid production - the only sweetening ingredient that actively benefits the oral microbiome while performing its flavour function.

Key benefits

• Oral bacteria cannot ferment xylitol, unlike sucrose
• Selects for less virulent oral bacteria with regular use
• GI ~7: minimal blood glucose and insulin impact
• Improves palatability of a 50-ingredient formula
• Birch-derived, non-GMO

The research

Peer-reviewed human trials supporting this ingredient at this dose.

1. Mäkinen KK. (2011). Med Princ Pract. 20(4):303-20.Sugar alcohol sweeteners as alternatives to sugar with special consideration of xylitol.PubMed →
2. Nayak PA, et al. (2014). Clin Cosmet Investig Dent. 6:89-94.The effect of xylitol on dental caries and oral flora.PubMed →
3. Shakhsi Niaee M, et al. (2024). Sci Rep. 14(1):16742.A chewing gum containing EDTA, MSM and xylitol works comparable to chlorhexidine mouthrinse.PubMed →

Works well with