Grape Seed Extract

200mg

≥95% OPCs - among the most potent antioxidants by ORAC. Supports endothelial function via the nitric oxide pathway. Synergises with Pine Bark Extract in this formula via the shared NO pathway.

Category Cardiovascular
Dose 200mg
Form ≥95% OPCs - MegaNatural-BP or equivalent
Evidence Level Moderate-Strong - multiple human trials

Mechanism

Grape seed extract is standardised for oligomeric proanthocyanidins (OPCs) - a class of condensed flavonoid polymers with among the highest antioxidant capacity measured by ORAC. OPCs support endothelial function by protecting nitric oxide from oxidative degradation by superoxide radicals, increasing NO bioavailability for vasodilation.

A 2011 meta-analysis of 9 RCTs found that GSE supplementation significantly reduced both systolic and diastolic blood pressure, with the largest effects in younger and metabolically dysregulated subjects. The OPC mechanism complements and synergises with pine bark procyanidins - both act on the same endothelial NO pathway.

Key Benefits

  • Among the highest ORAC values of any plant compound
  • Protects NO from superoxide degradation
  • Standardised to ≥95% OPCs by UV-Vis
  • Synergistic with Pine Bark Extract (shared NO pathway)
  • ≥95% OPC standardisation for consistent potency

The Research

Peer-reviewed human trials supporting this ingredient at this dose.

Feringa HH, et al. (2011). J Am Diet Assoc. 111(8):1173-81.The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials.PubMed →
Schön C, et al. (2021). Nutrients. 13(2):654.Grape seed extract positively modulates blood pressure and perceived stress.PubMed →
Weseler AR, Bast A. (2010). Curr Hypertens Rep. 12(3):154-61.Oxidative stress and vascular function: implications for pharmacologic treatments.PubMed →
In the formula

Grape Seed Extract

200mg

≥95% OPCs - MegaNatural-BP or equivalent

When to take it

Any time of day. Fat-soluble polyphenols - take with food for best absorption.

Works well with

Cardiovascular Pine Bark Extract 150mg Cardiovascular Olive Leaf Extract 500mg Mitochondrial Ubiquinol (CoQ10) 100mg
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