Niacinamide (B3)
Precursor to NAD+ - the coenzyme involved in over 500 enzyme reactions and all energy metabolism pathways. NAD+ declines markedly with age. Niacinamide (not niacin) has no flushing effect. Also required for DNA repair via PARP enzyme activation.
Mechanism
Niacinamide (nicotinamide) is a precursor to NAD+ (nicotinamide adenine dinucleotide) - the most central coenzyme in cellular metabolism, participating in over 500 enzyme reactions including all three energy metabolism pathways: glycolysis, the Krebs cycle, and oxidative phosphorylation. NAD+ also functions as a substrate for sirtuins (longevity-associated protein deacetylases) and PARP enzymes (DNA damage repair).
NAD+ is the central coenzyme in energy metabolism and is the subject of extensive research across mitochondrial and cellular biology. Niacinamide is chosen over nicotinic acid (niacin) specifically because it does not activate the GPR109A receptor that causes the intense skin flushing reaction - making it well-tolerated for daily use.
Key Benefits
- Precursor to NAD+ - the central coenzyme in energy metabolism
- Required for PARP-mediated DNA damage repair
- Vitamin B3 contributes to normal energy-yielding metabolism (GB NHC-authorised)
- Vitamin B3 contributes to the reduction of tiredness and fatigue (GB NHC-authorised)
- Non-flushing: niacinamide vs niacin
The Research
Peer-reviewed human trials supporting this ingredient at this dose.
Niacinamide (B3)
500mgNiacinamide - non-flushing form
Any time of day. Niacinamide does not cause the prostaglandin-mediated flushing associated with nicotinic acid (niacin). Can be taken at any time without GI sensitivity concerns.