Why 2.2mg of Vitamin B1?

How Vitamin B1 works

Thiamine pyrophosphate (TPP) - the active coenzyme form of B1 - is required for three key enzyme complexes: pyruvate dehydrogenase (linking glycolysis to the Krebs cycle), alpha-ketoglutarate dehydrogenase (in the Krebs cycle itself), and transketolase (in the pentose phosphate pathway). Without thiamine, glucose cannot be fully oxidised for ATP production.

Neural and cardiac tissue are particularly vulnerable to thiamine deficiency because of their extremely high metabolic rates and near-complete dependence on glucose oxidation. Thiamine is also required for acetylcholine synthesis, GABA production, and nerve conduction - all neurotransmitter processes that depend on adequate energy metabolism.

Key benefits

• Essential cofactor for pyruvate dehydrogenase (glucose → ATP)
• Required for Krebs cycle and pentose phosphate pathway
• Neural and cardiac tissue particularly dependent on thiamine
• Supports acetylcholine synthesis and nerve conduction
• 1.1mg = 100% NRV

The researchGB-NHC

Peer-reviewed human trials supporting this ingredient at this dose.

1. Lonsdale D. (2006). Evid Based Complement Alternat Med. 3(1):49-59.A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives.PubMed →
2. Sambon M, et al. (2021). Int J Mol Sci. 22(11):5418.Neuroprotective effects of thiamine and precursors with higher bioavailability: focus on benfotiamine and dibenzoylthiamine.PubMed →
3. Dhir S, et al. (2019). Front Psychiatry. 10:207.Neurological, psychiatric, and biochemical aspects of thiamine deficiency in children and adults.PubMed →

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