MINERALS & TRACE ELEMENTS - RŌNIN V4.1
Why 75mcg of Molybdenum?
Essential cofactor for the four molybdoenzymes: xanthine oxidase, aldehyde oxidase, sulphite oxidase, and mitochondrial amidoxime reducing component. Required for normal sulphur amino acid catabolism and purine metabolism. 50mcg = 100% NRV.
- CATEGORY
- Micronutrients
- DOSE
- 75mcg
- FORM
- Sodium molybdate - pharmaceutical grade
- EVIDENCE LEVEL
- Strong - EFSA approved health claim
How Molybdenum works
Molybdenum is incorporated as the molybdenum cofactor (Moco) into four essential mammalian enzymes: xanthine oxidase/dehydrogenase (purine catabolism to uric acid); aldehyde oxidase (oxidation of aldehydes and heterocycles, including drug metabolism); sulphite oxidase (converting sulphite to sulphate - the final step in sulphur amino acid catabolism, essential for metabolising cysteine and methionine); and mitochondrial amidoxime reducing component (mARC).
The most clinically critical of these is sulphite oxidase - genetic molybdenum cofactor deficiency results in severe neurological damage from sulphite accumulation. While dietary deficiency is rare in adults, ensuring adequate intake completes the full mineral cofactor profile required for normal xenobiotic and sulphur metabolism.
Key benefits
- Cofactor for sulphite oxidase - essential for sulphur amino acid catabolism
- Required for xanthine oxidase (purine metabolism)
- Required for aldehyde oxidase (drug and xenobiotic metabolism)
- Completes the full molybdoenzyme set
- 50mcg = 100% NRV
The researchGB-NHC
Peer-reviewed human trials supporting this ingredient at this dose.
- Molybdenum cofactor biosynthesis and deficiency.PubMed →
- Molybdenum — a scoping review for Nordic Nutrition Recommendations 2023.PubMed →
- LLL 44-1 Micronutrients in clinical nutrition: trace elements.PubMed →
IN THE FORMULA
Molybdenum
75mcg
Sodium molybdate
WHEN TO TAKE IT
Any time of day. Molybdenum is well-absorbed regardless of timing or food matrix. 50mcg = 100% NRV.