Cardiovascular
A heart for the long haul.
Cardiovascular
What's happening
Cardiovascular health at the cellular level is determined by endothelial function, lipid oxidation status, mitochondrial efficiency in cardiac tissue, and the integrity of the arterial wall. CoQ10 concentrates in cardiac tissue because the heart's metabolic demand is among the highest in the body. It's the mitochondrial electron carrier between complexes I and III, and a lipid-phase chain-breaking antioxidant. Algal DHA is a substrate for the resolution-of-inflammation lipid mediators (SPMs) that govern endothelial inflammatory tone. NAC is a cysteine prodrug for glutathione synthesis. Glutathione protects endothelial cells from oxidative load. Olive Leaf Extract delivers oleuropein, the secoiridoid polyphenol behind the well-documented olive-leaf vascular research. Vitamin K2 MK-7 at 180 µg activates Matrix GLA Protein (MGP), the γ-carboxylation reaction that keeps calcium in bone matrix and away from the arterial wall.
Evidence. Peer-reviewed, PubMed-verified
Aged Garlic Extract. Ried meta-analysis of 20 controlled trials (Ried 2016, J Nutr); Ried 2020 RCT on arterial stiffness and gut microbiota (Ried 2020, Exp Ther Med); Ashraf 2013 RCT in essential hypertension (Ashraf 2013, Pak J Pharm Sci).
Olive Leaf Extract. 232-participant RCT at 500 mg twice daily over 8 weeks in stage-1 hypertension (Susalit 2010, Phytomedicine); Lockyer 2017 RCT, polyphenol-rich extract on BP and lipids (Lockyer 2017, Eur J Nutr); Stevens 2021 cardiovascular health markers RCT (Stevens 2021, Eur J Nutr).
Vitamin K2 MK-7. Rotterdam Study cohort, 4,807 participants, 7–10 year follow-up (Geleijnse 2004, J Nutr); 3-year MK-7 RCT in postmenopausal women at 180 µg/day (Knapen 2013, Osteoporos Int); Vermeer review of extra-hepatic K-dependent proteins (Vermeer 2012, Food Nutr Res).
CoQ10 (Ubiquinol). Langsjoen 2014 plasma-uptake comparison (Langsjoen 2014, Clin Pharmacol Drug Dev); Mantle 2020 absorption review (Mantle 2020, Antioxidants); Ernster 1995 biochemistry canonical (Ernster 1995, Biochim Biophys Acta).
Full register: /pages/research.
How Rōnin addresses it
| Ingredient | Dose | Role |
|---|---|---|
| Ubiquinol (CoQ10) | 100mg | Mitochondrial electron transport (complex I → III); lipid-phase antioxidant in cardiac tissue |
| Algal DHA | 250mg DHA | Substrate for resolution-of-inflammation lipid mediators; endothelial membrane composition |
| Olive Leaf Extract | 500mg | Oleuropein ≥20% by HPLC; endothelial NO modulation, vascular tone |
| Grape Seed Extract | 200mg | OPCs ≥95% by UV-Vis; antioxidant defence, endothelial NO bioavailability |
| NAC | 600mg | Cysteine prodrug for glutathione synthesis; endothelial cell protection |
| Aged Garlic Extract | 600mg | ≥18-month aged; stable S-allyl cysteine; arterial stiffness research |
| Vitamin K2 MK-7 | 180mcg | All-trans ≥98%; MGP γ-carboxylation; bone-vascular calcium balance |
| Pine Bark Extract | 150mg | Procyanidins ≥65%; endothelial NO bioavailability via cerebrovascular blood flow research |
All ingredients listed are included in the Rōnin Daily Formula at the stated doses. One daily scoop.