Pillar — Cardiovascular

100 mg

ubiquinol — the reduced, bioavailable form of mitochondrial CoQ10.

Mantle · Antioxidants 2020

The gap

Oxidative load builds silently. By the time you have a number to worry about, the architecture has already changed. Defend your floor decades before you need to.

The evidence

  1. 4x

    plasma CoQ10 uptake: ubiquinol vs ubiquinone in healthy adults

    Langsjoen · Clin Pharmacol Drug Dev 2014

  2. 500 mg

    olive leaf oleuropein dose used in published stage-1 hypertension RCTs

    Susalit · Phytomedicine 2010

  3. 8 weeks

    pine bark improves endothelial function in adults with cardiovascular risk factors

    Belcaro · Minerva Med 2022

What KōJō provides

Three inputs, dosed at the level the research used.

  1. Ingredient 1

    100 mg

    Ubiquinol (active CoQ10)

    Reduced form — the bioavailable state your mitochondria use. Bypasses age-related conversion decline; supports the electron transport chain between complexes I/II and III.

  2. Ingredient 2

    250 mg

    Algal DHA

    Vegan DHA from Schizochytrium — where fish get theirs. No fish-taste, no heavy-metal concerns. Endothelial and cognitive support.

  3. Ingredient 3

    1,450 mg total

    Polyphenol Quartet

    Olive leaf 500 mg + aged garlic 600 mg + grape seed 200 mg + pine bark 150 mg. Multi-mechanism vascular support, every dose published.

What to expect

It compounds. Give it the time.

  1. Week 1–4

    Polyphenols load.

    Olive leaf, garlic, grape seed, pine bark reach steady-state plasma concentrations. Endothelial function begins improving.

  2. Month 2–3

    CoQ10 fills the gap.

    Tissue ubiquinol concentrations recover. Mitochondrial output in cardiac and vascular tissue improves.

  3. Year 1+

    The slow-burn variables.

    The ones nobody talks about until it’s late. You’re defending the architecture decades before you need to.

Less noise. More proof.

Every dose published. Every ingredient sourced.

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